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ORIGINAL ARTICLE
Year : 2018  |  Volume : 7  |  Issue : 3  |  Page : 114-118

Effect of vaginal estriol use in total laparoscopic hysterectomy with gonadotropin-releasing hormone agonist therapy


1 Department of Gynecology, Yokohama City University Medical Center, Yokohama, Kanagawa, Japan
2 Departments of Gynecology and Obstetrics, Yokohama Municipal Citizen's Hospital, Yokohama, Kanagawa, Japan

Correspondence Address:
Dr. Go Hirata
Department of Gynecology, Yokohama City University Medical Center, 4-57 Urafune-Cho, Minami-Ku, Yokohama 232-0024, Kanagawa
Japan
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/GMIT.GMIT_57_18

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Study Objectives: The aim of this study is to evaluate the effects of vaginal estriol therapy in total laparoscopic hysterectomy (TLH) with gonadotropin-releasing hormone agonist (GnRH-a) treatment. Design: Retrospective analysis. Design Classification: Canadian Task Force classification II-2. Settings: Department of Gynecology, Yokohama City University Medical Center, Japan. Methods: We retrospectively investigated 50 fibroid cases that had TLH with preoperative GnRH-a treatment and compared the surgical outcome with or without vaginal estriol use (1mg). Estriol was used administered for two weeks before TLH. Measurements and Main Results: A total of 12 patients (27%) received vaginal estriol (1 mg) for 14 days before TLH. As a result of vaginal estriol treatment, there were no group differences in uterus size reduction with GnRH-a treatment (22% vs. 15%, P = 0.20), uterine removal time through the vagina (12.5 min vs. 18.5 min, P = 0.18), rate of vaginal dehiscence (3% vs. 0%, P = 0.76) or in the rate of perineal laceration (33% vs. 34%, P = 0.55). Conclusion: The use of vaginal estriol treatment before TLH with GnRH-a therapy did not improve surgical outcomes.


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