Year : 2018 | Volume
: 7 | Issue : 3 | Page : 119--123
Efficacy of hormonal therapies for decreasing uterine volume in patients with adenomyosis
Takashi Matsushima1, Shigeo Akira2, Takehiko Fukami1, Koichi Yoneyama1, Toshiyuki Takeshita2
1 Department of Obstetrics and Gynecology, Nippon Medical School Musashikosugi Hospital, Kawasaki, Japan
2 Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan
Study objective: The aim of this study is to evaluate the efficacy of hormonal therapies for inhibiting an increase in uterine volume in patients with adenomyosis.
Design: This was retrospective cohort study.
Setting: This study was conducted at Nippon Medical School Musashikosugi Hospital.
Patients: A total of 28 women diagnosed with adenomyosis using magnetic resonance imaging.
Methods: After providing informed consent, patients were treated with gonadotropin-releasing hormone agonist (GnRHa group), a low-dose estrogen and progestin combination (LEP group), or dienogest (DNG group) for ≥16 weeks. Uterine volume was assessed using the formula for an ovoid; uterine volumes before and after 16 weeks of treatment were compared. A <5% increase in uterine volume at 16 weeks was considered to reflect inhibition of uterine volume increase and efficacy of the medication. We compared the efficacy rate among the groups.
Results: In the GnRHa group, a significant reduction in uterine volume was noted, from 307.4 ± 230.1 to 177.9 ± 142.1 cm3 (P < 0.001). In the LEP and the DNG groups, there was no significant change (LEP: 226.7 ± 116.6 cm3 pre-treatment and 230.5 ± 128.6 cm3 post-treatment, P = 0.85; DNG: 232.6 ± 117.8 cm3 pre-treatment and 262.1 ± 136.8 cm3 post-treatment, P = 0.37). The number of responders (efficacy rate) in the GnRHa group, LEP group, and DNG group was 25/26 (96.2%), 7/15 (46.7%), and 6/11 (54.5%), respectively. The efficacy rate of GnRHa therapy was significantly higher than that of LEP or DNG therapy (P < 0.001 and P = 0.005, respectively).
Conclusion: We conclude that the efficacy of GnRHa in reducing uterine volume should be considered when prescribing hormone therapy for adenomyosis.
Dr. Takashi Matsushima
Department of Obstetrics and Gynecology, Nippon Medical School Musashikosugi Hospital 1-396 Kosugi-Cho, Nakahara-Ku, Kawasaki, Kanagawa 211-8533
|How to cite this article:|
Matsushima T, Akira S, Fukami T, Yoneyama K, Takeshita T. Efficacy of hormonal therapies for decreasing uterine volume in patients with adenomyosis.Gynecol Minim Invasive Ther 2018;7:119-123
|How to cite this URL:|
Matsushima T, Akira S, Fukami T, Yoneyama K, Takeshita T. Efficacy of hormonal therapies for decreasing uterine volume in patients with adenomyosis. Gynecol Minim Invasive Ther [serial online] 2018 [cited 2020 Aug 8 ];7:119-123
Available from: http://www.e-gmit.com/article.asp?issn=2213-3070;year=2018;volume=7;issue=3;spage=119;epage=123;aulast=Matsushima;type=0