Gynecology and Minimally Invasive Therapy

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 8  |  Issue : 2  |  Page : 59--61

Salivary human chorionic gonadotropin as a novel biomarker for early detection of pregnancy: A pilot study


Madhura Mahajan1, Uzma Iqbal Belgaumi2, Rajendra Baad2, Nupura Vibhute2, Vidya Kadashetti2, Sushma Bommanavar2, Wasim Kamate2 
1 Intern, School of Dental Sciences, KIMSDU, Karad, Maharashtra, India
2 Department of Oral Pathology and Microbiology, School of Dental Sciences, KIMSDU, Karad, Maharashtra, India

Correspondence Address:
Dr. Uzma Iqbal Belgaumi
Department of Oral Pathology and Microbiology, School of Dental Sciences, KIMSDU, Karad, Maharashtra
India

Context: The role of saliva in detection of pregnancy has not received the due importance it deserves. Aims: The present paper aims at determining the role of saliva in detection of pregnancy using home-based pregnancy detection kits to provide an alternative biofluid that is more user friendly, acceptable, noninvasive, rapid, and easy for home use. Settings and Design: The study was conducted among 35 women visiting a gynecology clinic for confirmation of pregnancy, who gave a history of a missed menstrual cycle not more than 4 weeks. Subjects and Methods: A home-based pregnancy detection kit meant for urinary human chorionic gonadotropin (hCG) detection with 20 mIU specification was used in the study for estimation of salivary hCG. Routine test that was prescribed to the patient such as laboratory-based urine hCG and/or ultrasound examination was used for confirmation of pregnancy status and correlation with the saliva-based result. Results: A positive test was obtained in 74% participants, with a dark band in 43% participants and a light band in 31% participants. A negative result was noted in 26% participants. We observed that salivary hCG estimation showed a 77% accuracy and 23% false-negative results. Conclusions: An astounding 74% of participants showed a positive result with an existing pregnancy kit which indicates a strong plausibility of using salivary hCG as a biomarker for detection of pregnancy. With the findings obtained from our study, we could positively affirm that salivary hCG can be used as a potential, user friendly, and more acceptable biomarker for early detection of pregnancy.


How to cite this article:
Mahajan M, Belgaumi UI, Baad R, Vibhute N, Kadashetti V, Bommanavar S, Kamate W. Salivary human chorionic gonadotropin as a novel biomarker for early detection of pregnancy: A pilot study.Gynecol Minim Invasive Ther 2019;8:59-61


How to cite this URL:
Mahajan M, Belgaumi UI, Baad R, Vibhute N, Kadashetti V, Bommanavar S, Kamate W. Salivary human chorionic gonadotropin as a novel biomarker for early detection of pregnancy: A pilot study. Gynecol Minim Invasive Ther [serial online] 2019 [cited 2019 Aug 18 ];8:59-61
Available from: http://www.e-gmit.com/article.asp?issn=2213-3070;year=2019;volume=8;issue=2;spage=59;epage=61;aulast=Mahajan;type=0